Dr. Ballas's clinical interests place major emphasis on the evaluation of immune dysfunction. In particular, he examines patients with possible abnormalities in distinct components of the immune system such as NK cells, CD8, CD4 or B lymphocytes as well as neutrophil deficiency. He is also interested in patients with impaired wound healing. Other clinical interests include allergic problems, drug reactions in particular, and the clinical use of biological response modifiers. Dr. Ballas's research examines the role of lymphokines in cell-mediated immune responses and transplantation, the role of killer cells in tumor immunity and the modulation of in vivo immune responses with particular emphasis on inflammatory and malignant disease. The research focus is placed on the role of NK cells in health and disease. This topic is explored in bench research endeavors, in translational research and in clinical research.

Current research projects are as follows:

  1. Augmentation of NK cell activity by CpG oligodeoxynucleotides (ODN) and their use in tumor immunotherapy;
  2. NK cell activity in alcoholism;
  3. Clinical spectrum of patients with NK cell deficiency;
  4. Assessment of immune function in patients with classical primary immunodeficiency;
  5. Assessment of non-classical immune disorder in children and adults including attenuated immunodeficiency. 

Select Publications

A Personalized Diagnostic and Treatment Approach for Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Adults.
Kumar B, Aleem S, Saleh H, Petts J, Ballas ZK.
J Clin Immunol. 2017 Sep 4. doi: 10.1007/s10875-017-0439-x.

The Journal of Allergy and Clinical Immunology: An update on style and substance.
Akdis CA, Byrne J, Ballas ZK.
J Allergy Clin Immunol. 2017 Jul;140(1):60-62. doi: 10.1016/j.jaci.2017.05.009.

The future of allergy/immunology: Promising young investigators.
Akdis CA, Ballas ZK.
J Allergy Clin Immunol. 2017 Aug;140(2):384-386. doi: 10.1016/j.jaci.2017.06.001. Epub 2017 Jun 15

Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry.
Mayor PC, Eng KH, Singel KL, Abrams SI, Odunsi K, Moysich KB, Fuleihan R, Garabedian E, Lugar P, Ochs HD, Bonilla FA, Buckley RH, Sullivan KE, Ballas ZK, Cunningham-Rundles C, Segal BH.
J Allergy Clin Immunol. 2017 Jun 9. pii: S0091-6749(17)30925-9. doi: 10.1016/j.jaci.2017.05.024. 

Biologic response modifiers: Indications, implications, and insights.
Davis BP, Ballas ZK.
J Allergy Clin Immunol. 2017 May;139(5):1445-1456. doi: 10.1016/j.jaci.2017.02.013. Epub 2017 Mar 2. Review.

Gastrointestinal Manifestations in X-linked Agammaglobulinemia.
Barmettler S, Otani IM, Minhas J, Abraham RS, Chang Y, Dorsey MJ, Ballas ZK, Bonilla FA, Ochs HD, Walter JE.
J Clin Immunol. 2017 Apr;37(3):287-294. doi: 10.1007/s10875-017-0374-x. Epub 2017 Feb 24.

Antibody deficiency in patients with frequent exacerbations of Chronic Obstructive Pulmonary Disease (COPD).
McCullagh BN, Comellas AP, Ballas ZK, Newell JD Jr, Zimmerman MB, Azar AE.
PLoS One. 2017 Feb 17;12(2):e0172437. doi: 10.1371/journal.pone.0172437. eCollection 2017.

All Publications

See Dr. Ballas's complete list of publications on PubMed.